Effects of aging on structure and stability of TiO2 nanoparticle-containing oil-in-water emulsions.
Identifieur interne : 000350 ( Main/Exploration ); précédent : 000349; suivant : 000351Effects of aging on structure and stability of TiO2 nanoparticle-containing oil-in-water emulsions.
Auteurs : Manon Rossano [France] ; Nicolas Hucher [France] ; Céline Picard [France] ; Daniel Colletta [France] ; Frank Le Foll [France] ; Michel Grisel [France]Source :
- International journal of pharmaceutics [ 1873-3476 ] ; 2014.
English descriptors
- KwdEn :
- Chemistry, Pharmaceutical (methods), Colloids, Drug Storage, Emulsions, Microscopy, Nanoparticles, Oils (chemistry), Particle Size, Rheology, Sunscreening Agents (administration & dosage), Sunscreening Agents (chemistry), Surface Properties, Temperature, Time Factors, Titanium (administration & dosage), Titanium (chemistry), Water (chemistry).
- MESH :
- chemical , administration & dosage : Sunscreening Agents, Titanium.
- chemical , chemistry : Oils, Sunscreening Agents, Titanium, Water.
- chemical : Colloids, Emulsions.
- methods : Chemistry, Pharmaceutical.
- Drug Storage, Microscopy, Nanoparticles, Particle Size, Rheology, Surface Properties, Temperature, Time Factors.
Abstract
Formulations incorporating different cosmetic grade TiO2 nanoparticles were developed according to a self-produced protocol on the basis of typical sunscreen cream oil-in-water emulsions. Role of nanoparticles and, more specifically, the impact of two different lipophilic surface treatments on microstructure and stability of the formulations were assessed. Aging of formulations was performed under classical conditions at room temperature or under accelerated conditions at 50 °C, with or without TiO2, and was characterized by several tools such as rheology, microscopy, and particle size measurements. Changes in emulsion stability and aggregation state of nanoparticles were followed over time. Destabilization phenomena were identified: under accelerated aging, the formulation without nanoparticles underwent a coalescence occurrence whereas the formulation incorporating nanoparticles was subjected to aggregation of the colloidal particles. Besides, TiO2 nanoparticles strongly affected the particle-droplets interactions and thus modified the emulsion microstructure with a coating-dependent effect: destabilization mechanisms occur more rapidly with alumina (and) triethoxycaprylylsilane (coating 1) TiO2 nanoparticles as compared to alumina (and) isopropyl titanium triisostearate (and) triethoxycaprylylsilane crosspolymer (coating 2) nanoparticles.
DOI: 10.1016/j.ijpharm.2013.11.039
PubMed: 24291079
Affiliations:
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LEMA, EA 3222, University of Le Havre, 25 rue Philippe Lebon B.P. 540, 76058 Le Havre Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>URCOM, EA 3221, FR CNRS 3038, University of Le Havre, 25 rue Philippe Lebon B.P. 540, 76058 Le Havre Cedex, France; LEMA, EA 3222, University of Le Havre, 25 rue Philippe Lebon B.P. 540, 76058 Le Havre Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Hucher, Nicolas" sort="Hucher, Nicolas" uniqKey="Hucher N" first="Nicolas" last="Hucher">Nicolas Hucher</name><affiliation wicri:level="3"><nlm:affiliation>URCOM, EA 3221, FR CNRS 3038, University of Le Havre, 25 rue Philippe Lebon B.P. 540, 76058 Le Havre Cedex, France. Electronic address: nicolas.hucher@univ-lehavre.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>URCOM, EA 3221, FR CNRS 3038, University of Le Havre, 25 rue Philippe Lebon B.P. 540, 76058 Le Havre Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Picard, Celine" sort="Picard, Celine" uniqKey="Picard C" first="Céline" last="Picard">Céline Picard</name><affiliation wicri:level="3"><nlm:affiliation>URCOM, EA 3221, FR CNRS 3038, University of Le Havre, 25 rue Philippe Lebon B.P. 540, 76058 Le Havre Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>URCOM, EA 3221, FR CNRS 3038, University of Le Havre, 25 rue Philippe Lebon B.P. 540, 76058 Le Havre Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Colletta, Daniel" sort="Colletta, Daniel" uniqKey="Colletta D" first="Daniel" last="Colletta">Daniel Colletta</name><affiliation wicri:level="3"><nlm:affiliation>URCOM, EA 3221, FR CNRS 3038, University of Le Havre, 25 rue Philippe Lebon B.P. 540, 76058 Le Havre Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>URCOM, EA 3221, FR CNRS 3038, University of Le Havre, 25 rue Philippe Lebon B.P. 540, 76058 Le Havre Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Le Foll, Frank" sort="Le Foll, Frank" uniqKey="Le Foll F" first="Frank" last="Le Foll">Frank Le Foll</name><affiliation wicri:level="3"><nlm:affiliation>LEMA, EA 3222, University of Le Havre, 25 rue Philippe Lebon B.P. 540, 76058 Le Havre Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>LEMA, EA 3222, University of Le Havre, 25 rue Philippe Lebon B.P. 540, 76058 Le Havre Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Grisel, Michel" sort="Grisel, Michel" uniqKey="Grisel M" first="Michel" last="Grisel">Michel Grisel</name><affiliation wicri:level="3"><nlm:affiliation>URCOM, EA 3221, FR CNRS 3038, University of Le Havre, 25 rue Philippe Lebon B.P. 540, 76058 Le Havre Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>URCOM, EA 3221, FR CNRS 3038, University of Le Havre, 25 rue Philippe Lebon B.P. 540, 76058 Le Havre Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName></affiliation></author></analytic><series><title level="j">International journal of pharmaceutics</title><idno type="eISSN">1873-3476</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chemistry, Pharmaceutical (methods)</term><term>Colloids</term><term>Drug Storage</term><term>Emulsions</term><term>Microscopy</term><term>Nanoparticles</term><term>Oils (chemistry)</term><term>Particle Size</term><term>Rheology</term><term>Sunscreening Agents (administration & dosage)</term><term>Sunscreening Agents (chemistry)</term><term>Surface Properties</term><term>Temperature</term><term>Time Factors</term><term>Titanium (administration & dosage)</term><term>Titanium (chemistry)</term><term>Water (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Sunscreening Agents</term><term>Titanium</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Oils</term><term>Sunscreening Agents</term><term>Titanium</term><term>Water</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Colloids</term><term>Emulsions</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Chemistry, Pharmaceutical</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Drug Storage</term><term>Microscopy</term><term>Nanoparticles</term><term>Particle Size</term><term>Rheology</term><term>Surface Properties</term><term>Temperature</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Formulations incorporating different cosmetic grade TiO2 nanoparticles were developed according to a self-produced protocol on the basis of typical sunscreen cream oil-in-water emulsions. Role of nanoparticles and, more specifically, the impact of two different lipophilic surface treatments on microstructure and stability of the formulations were assessed. Aging of formulations was performed under classical conditions at room temperature or under accelerated conditions at 50 °C, with or without TiO2, and was characterized by several tools such as rheology, microscopy, and particle size measurements. Changes in emulsion stability and aggregation state of nanoparticles were followed over time. Destabilization phenomena were identified: under accelerated aging, the formulation without nanoparticles underwent a coalescence occurrence whereas the formulation incorporating nanoparticles was subjected to aggregation of the colloidal particles. Besides, TiO2 nanoparticles strongly affected the particle-droplets interactions and thus modified the emulsion microstructure with a coating-dependent effect: destabilization mechanisms occur more rapidly with alumina (and) triethoxycaprylylsilane (coating 1) TiO2 nanoparticles as compared to alumina (and) isopropyl titanium triisostearate (and) triethoxycaprylylsilane crosspolymer (coating 2) nanoparticles.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Haute-Normandie</li><li>Région Normandie</li></region><settlement><li>Le Havre</li></settlement></list><tree><country name="France"><region name="Région Normandie"><name sortKey="Rossano, Manon" sort="Rossano, Manon" uniqKey="Rossano M" first="Manon" last="Rossano">Manon Rossano</name></region><name sortKey="Colletta, Daniel" sort="Colletta, Daniel" uniqKey="Colletta D" first="Daniel" last="Colletta">Daniel Colletta</name><name sortKey="Grisel, Michel" sort="Grisel, Michel" uniqKey="Grisel M" first="Michel" last="Grisel">Michel Grisel</name><name sortKey="Hucher, Nicolas" sort="Hucher, Nicolas" uniqKey="Hucher N" first="Nicolas" last="Hucher">Nicolas Hucher</name><name sortKey="Le Foll, Frank" sort="Le Foll, Frank" uniqKey="Le Foll F" first="Frank" last="Le Foll">Frank Le Foll</name><name sortKey="Picard, Celine" sort="Picard, Celine" uniqKey="Picard C" first="Céline" last="Picard">Céline Picard</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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